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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44771

POTENTIAL OF DIFFERENT SOLID DISPERSION TECHNIQUES TO ENHANCE THE SOLUBILITY AND DISSOLUTION RATE OF PALBOCICLIB

T.Naga Aparna, A.Samba SivaRao

Abstract

The main objective of the present investigation was to improve the Solubility and dissolutionrate of Palbociclib a poorly water-soluble drug by solid dispersion techniques. The soliddispersions of Palbociclib were prepared by three different techniques namely surface soliddispersion (SSD1- SSD15), melt granulation (MG1-MG15) and liquisolid compacts (LSC1-LSC9).Prepared soliddispersions have been evaluated for various properties. The best optimized formulation was chosen based on in-vitro release studies and the optimized formulation, which showed the highest dissolution rate was further characterized for FTIR,XRD, surface morphology and stability studies. The study showed that prepared solid dispersion has shown satisfactory results for all the evaluated parameters. The solubility of Palbociclib was found to be more from solid dispersions compared to pure drug. The rate ofdrug release was found to be higher in all the prepared solid dispersions and among all, soliddispersions prepared by Melt granulation technique with highest drug release exhibited byMG 3 of 99.68% and the hierarchy from the dissolution results follows the rank order MG3>LSC 1>SSD 3. The optimised formulation MG 3 was then characterised for FTIR whichdisclosednospecificinteractionsbetweendrugandexcipientsandXRD, SEM results showed the amorphous form of Palbociclib in the formulation. The stability studies proposed that MG3 formulation was stable over 3months. ThestudyconcludesthatthesoliddispersionofPalbociclib canbe effectively prepared using Meltgranulation technique.

Keywords

Palbociclib,Chemotherapeuticagent,Solubility,Surfacesoliddispersion,Dissolution

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