DOI: 10.14704/nq.2022.20.8.NQ44769

An Overview of Expression of Livin Gene in Acute Lymphoblastic Leukemia

Hosneia Khalaf Akl, Amina Mohamed Talaat, Mervat Abd Allah Hesham , Sara Mohamed Mohamed Ibrahim

Abstract

Background: Acute lymphoblastic leukemia (ALL) represents approximately 80% of childhood leukemias, making it the most common childhood malignancy. Apoptosis is an autonomous process that involves the activation, expression, and regulation of a wide range of genes, leading to programed cell death to remove unwanted or abnormal cells. Livin/ML- IAP/BIRC7 is a member of the inhibitor of apoptosis proteins family, which plays a key role in the regulation of apoptosis and modulation of cell cycle and cell proliferation. Livin is over-expressed in several cancer types and presents an anti-apoptotic activity mediated mostly by the direct inhibition of caspase 3, but also of caspases 7 and 9 and DIABLO

Keywords

Livin, Acute Lymphoblastic Leukemia

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