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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44700

A Formulation Approach to Explore the Antibacterial Potential of Chromolaena Odorata on Burn Wounds

Gowtham M, Dhole Snehal, Kashid Girish, Shendge Raosaheb, Pawar Sarita, Pattewar Seema

Abstract

The incorporation Chromolaena Odorata leaf extract in silver shows higher antibacterial activity. We aimed to utilize the topical drug delivery technique refers to the application of any agents or drugs directly to the skin at the site of infection or wound to deliver the drug to the dermal layer as well as the underlying tissue. In this research work, the leaf of Chromolaena Odorata was extracted by soxhlet extraction. The optimized silver nanoparticle was evaluated for SEM, XRD, zeta potential, particle size, and in vitro antibacterial activity by comparing the results of the complex with the extract. The average particle size was found to be 223.4nm. the antibacterial inhibitory efficacy of prepared nanogel was found similar to the marketed product (burn heal)against the staphylococcus aureus and pseudomonas aeruginosa. This result indicates that the silver nanogel could be considered an effective drug delivery system for improving the overall bioavailability, unique structural diversity, and a better safety profile, solubility, and permeability, for burn wound healing.

Keywords

SILVER NANOPARTICLE, SILVER NANOGEL, ANTIBACTERIAL ACTIVITY, CHROMOLAENA ODORATA.

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