DOI: 10.14704/nq.2022.20.8.NQ44697

EFFICACY OF ANTICANCER BIO-ACTIVE COMPOUND THROUGH THE NATURAL TRIBE CASTALIN

J. Praveen kumar, P. Geetha

Abstract

Our present work investigated the efficiency of encapsulation of castalin in poly (lactic-co- glycolic acid) (PLGA) nanoparticles using solid/oil/water emulsion solvent evaporation method. The relevance of nanotechnology to drug delivery systems for cancer therapy has progressively received great attention.. Castalin has been initiate to be very efficacious against many different types of cancer cells. to conclude, the in vivo anti-tumor activity of Castalin-loaded PLGA NPs was evaluated in tumor-bearing mice. The NPs obtained had smooth surfaces with particle sizes ranged from 160 ± 3.05 to 164 ± 8.7 nm with slightly positive surface charge ranged from 1.02 ± 0.12 to 3.71 ± 0.44 mV. Entrapment of Castalin ranged between 84.5 ± 1.8% and 86 ± 1.3% with yields not less than 100.32%. Total protein adsorbed was less than 24.5 μg total protein/1 mg NP. In vitro drug liberate was less than 88.1% at 12 h. to finish, significant reductions in tumor growth rate and mortality rate were observed for PLGA NP formulations compared to both Castalin solution and naked NPs.

Keywords

Nanoparticles; PLGA; Castalin; cancer; sustained release; in vivo rat model.

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