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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44644

Polymorphism impact on AGTR1 gene in Covid-19 patients in Babylon Province

Zainab A. Tolaifeh, Nada naji shaalan, Abeer Fauzi Al-Rubaye, Maani seher Abid AL-Kafaji

Abstract

Infection by the Covid-19 produces in people an illness of profoundly factor and erratic seriousness. The presence of continuous hereditary single nucleotide polymorphisms (SNPs) in the population could prompt a more prominent weakness to infections or an overstated provocative reaction. We concentrated on the relationship between SNP from AGTR1 gene and the seriousness of the infection created by the SARS-Cov-2 infection. Methods: 30 (18 of male and 12 of Female) Covid-19 patients with age range from 55-60 years were assembled in light of the seriousness of side effects. Results: one SNP rs5186 in AGTR1 gene were related with the seriousness of illness. Our results were showed that the rs5186 (C) allele in AGTR1 gene is associated with increased risk for Covid 19 based on OR value: homozygous allele CC has 2.5(0.7-8.5), allele C with allele frequency 20 more than control group, and with OR=2.5(1.5-5.9) with significant P values (P=0.03).

Keywords

Covid-19, AGTR1 gene, SNP rs5186. Allele frequency.

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