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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44620

Clinical and biochemical (PH level) effects of platelet-rich fibrin on skin pedicle graft healing

Muhammad J. Muhammad, Rafid M. Naeem


Objective: Surgical Procedures with skin damage range from scaling and planning to complex procedures such as skin graft surgery. Healing following such damage is crucial to predicting the prognosis of the treatment. Aim: The study aimed to investigate the impact of allogenic PRF on skin pedicle graft in treating experimental avulsion wounds from a clinical and biochemical standpoint (PH level). Materials and method: The experiment was performed on 15 adult female goats aged between 7-8 months and weighing 18-20 Kg. Surgery was performed under heavy sedation and created complete aseptic conditions, 2 skin marks (2×2 cm) on both sides of the trunk region of the animal. Two full thickness of the blotchy skin is cut carefully. Advancement or sliding flaps (2×6 cm) are harvested parallel to the least tension lines and slid over the adjacent wound. These wounds are allocated into two groups, the first one as the control group and the second group treated with autogenic platelet-rich fibrin. The two groups are represented in each goat. The edges of the wounds were closed by 2-0 nylon monofilament sutures. Results: Clinical examination showed the amount of wound exudation in the treated group significantly increased compared to the control group. The swelling of the grafts in the treated group disappeared within the next three postoperative days. However, in the control group, it was greater and remained for a longer period, as it continued until the seventh day. Biochemically, PH levels were greater in the surgically treated group on days five, seven, and fourteen after surgery than in the control groups. There was also a considerable rise in the control group. But on day twenty-one, there was no significant difference between the control and normal groups. Still, the pH level in the treated group rose significantly. Conclusion: PRF accelerates the inflammatory stage, speeding up the proliferation stage, and promotes the healing process. PRF may increase the pH level in the pedicle grafts and restore a normal environment in the wound.


gout, pedicle graft, PRF, wound, acidity.

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