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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44585

Antioxidant status and the in vitro effect of Trypsin and Chymotryps in enzymes on Iraqi pancreatic cancer patients.

Maha Y. Thabeet , Dr.Firas A.Hassan

Abstract

cancer of the pancreas Pancreatic cancer has been identified as the 11th most prevalent cancer in the world. It is an incurable malignancy and the seventh major cause of cancer deaths globally in industrialized nations. 100 blood samples were obtained from AL-Anbar oncology cancer and the nearby Baghdad Hospital. Two groups were created out of them. The first group consists of 30 pancreatic cancer patients between the ages of 20 and 40, while the second group consists of 30 patients between the ages of 41 and 60, with 20 healthy individuals serving as the control group. Measurements were made to gather biological data to aid in the early diagnosis of the illness. The concentration of Trypsin enzyme in the serum of pancreatic cancer patients increased, while the concentration of Chymotrypsin enzyme and D3 decreased when compared to the control group, according to the results of the measurements of the two groups' levels of antioxidant vitamins (E and D3) and enzymes (Trypsin and chymotrypsin). Vitamin E level has no impact . Materials and Methods the total number of blood samples collected was 80 samples. 40 blood samples of pancreatic cancer patients of different ages 20-60 years , including patients without chronic diseases Such as blood pressure, diabetic , heart disease, those with a family history of pancreatic cancer , and smokers (group A) of 80 samples Blood There are 40 samples of healthy controls (Group B). healthy controls has been selectedwithout chronic diseases or a family history of pancreatic cancer or other cancers. Results: According to our research, people with Pancreatic cancer had significantly high concentration levels of trypsin while the concentration of Chymotrypsin enzyme and D3 decreased when compared to the control group, according to the results of the measurements of the two groups' levels of antioxidant vitamins (E and D3) and enzymes (Trypsin and chymotrypsin). Vitamin E level has no impact . Conclusion: In our study, we can conclude that pancreatic cancer patients exhibited a significant reduction in the level chymotrypsin enzyme and antioxidant vitamin D3 ,while it showed an increase in the trypsin enzyme and vitamin E not effected. Aims 1. Study the change in levels of enzymes (Trypsin and Chymotrypsin) in pancreatic cancer patient as compared with the control group . 2.evaluate the role of some antioxidants represented by vitamin D3and Vitamin E in development of pancreatic cancer

Keywords

cancer of the pancreas Pancreatic cancer has been identified as the 11th most prevalent cancer in the world.

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