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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44567

EVALUATION OF HERBAL OINTMENT CONTAINING ETHANOLIC EXTRACT OF STEM BARK OF Berberis aristata DC. FOR ITS ANTIPSORIATIC AND ANTIINFLAMMATORY POTENTIALITY

Saumya Das, Anamika, Nashra, Shobhini Chandel

Abstract

Objective: Berberis aristataDC. is traditionally used medicinal plant and having a wide therapeutic effect for the treatment of different kinds of illnesses. The aim of this present research work was to evaluate the anti-psoriatic activity and anti-inflammatory activity of plant Berberis aristata DC. (stem bark). Methods: Screening for phytochemicals was performed to investigate the inclusion of plant-based components in Berberis aristata DC. (stem bark). To evaluate the anti-psoriatic activity of Berberis aristata DC (stem bark) on Swiss albino mice tail model was used. Then Evaluation parameters (redness, erythema and scales) were observed and histopathological examination was performed to observe the symptoms and changes in epidermal thickness of mice skin. Safety profile of Berberis aristata DC. was confirmed by acute dermal toxicity test by following OECD guideline 402. For anti-inflammatory activity of Berberis aristata DC. (stem bark) on Wistar rats histamine induced paw edema model was used. Three hours after an intraplantar injection of histamine, the number of neutrophils in tissue samples from the paws was counted. Results: In present study findings, the phytochemicals were found to be alkaloids, flavonoids, coumarins, glycosides, polyphenols, saponins and tannins. BAEE ointments 0.5% and 1% w/w were more significant towards anti-psoriatic activity. The dose of 400mg/kg was more potent towards antiinflammatory activity. Conclusion: From theobserved findings it was concluded that BAEE has therapeutic efficacy for the management and treatment of psoriasis and inflammatory activity.

Keywords

Phytochemical, inflammation, OECD, psoriatic, Berberis aristata DC. epidermal thickness, munro micro abscess, spleen index, acute dermal toxicity.

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