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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44557

Short and long-term effects of Trigonelline on behavioural functions, biochemical and haematological parameters in Sprague Dawley rats

Vimalah Devi Gengathurai, Usha Kumari, Victor David, Subramani Parasuraman, Baala Sharmma, Sherly Deborah George

Abstract

Objective: The present study was planned to study the short and long-term effect of trigonelline (TGN) on behavioural functions, biochemical and haematological parameters in Sprague Dawley (SD) rats. Methodology: The male rats were divided into five groups with each of six animals (short and long-term). In short-term study, the rats were treated for 7 days and in long-term study the rats were treated for 45 days. The rats were treated with vitamin C (200 mg/kg) or TGN (12.5/ 25 / 50 mg/kg). The changes in behaviour functions, biochemical and haematological parameters of the experimental animals were monitored at the regular intervals. Results: In short-term study, the animals treated with vitamin C and TGN did not show any significant changes in locomotor activity, grip strength and Escape Latency Time (ELT) when compared with that of control whereas the animals treated with TGN for 45 days (chronic study), showed a significant increase in locomotor activity and reduction in ELT when compared with control. The animal treated with vitamin C or TGN for 7 days, did not show any significant changes in biochemical and haematological parameters, whereas the animals treated with TGN for 45 days showed a significant change in the levels of AST, ALT, creatinine, and urea when compared with control. Conclusion: Trigonelline improved the locomotor activity and alertness in long-term administration without affecting liver functions and haematological parameters. Long-term administration of Trigonelline improved the locomotor activity and alertness without affecting liver functions and haematological parameters.

Keywords

Grip strength, Escape latency time, Locomotor activity, Vitamin C.

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