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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44531

Natural polymer based mucoadhesive gastroretentive tablets of Pregabalin: formulation and in vitrocharacterization

Aradhana Tiwari, Komal Manwani, Mohd. Kalim, Dr. Prashant Kumar Katiyar

Abstract

The aim of this investigation was to formulate gastroretentive tablets of pregabalin utilizing the potential of natural gums as mucoadhesive polymer so that the formulation could control the release of the drug thereby reducing its dosing frequency and improving the bioavailability. The angle of repose, bulk density, tapped density, Hausner’s ratio and Carr’s Index were found to be ranging from23.78 ± 0.5468° to 26.54 ± 0.2939°, 0.39 ± 0.0435 to 0.533 ± 0.0208 g/cm3 , 0.476 ± 0.0152 to 0.596 ± 0.0251 g/cm3 , 1.05 to 1.24 and 4.82 to 19.38 respectively. The thickness of tablets was 4.9 to 4.8 mm, hardness 4.5 kg/cm2 and 4.1 kg/cm2 , friability 0.19% to 0.49% and the weight variation 1.8 to 1.2 %.Swelling study was performed on all the formulation for 9 h and was found to be in the range of 2.23 to 6.08. The highest degree of swelling was achieved by F7 containing a mixture of all the three gums. All the formulations were able to prolong the release of drug for more than 10 hours. Formulation F6 and F7 were able to sustain the release to higher duration with F6 and F7 releasing 87.2 and 81.6 % pregabalin respectively at the end of the 12 hours of study.

Keywords

Pregabalin, sustained release, gastroretentive, mucoadhesion, natural gum

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