DOI: 10.14704/nq.2022.20.8.NQ44509

FORMULATION AND EVALUATION OF TURMERIC EMULGEL FOR ANTI-INFLAMMMATORY ACTIVITY

Archana. G. L , K. Srisailam , M. Nagulu

Abstract

The aim of the present research work was to investigate the potential of emulgel in enhancing the topical delivery of Turmeric. Emulgel formulations of Turmeric were prepared using Carbopol 934 and Carbopol 940 as gelling agents. The main purpose of this research was to formulate and evaluate a topical gellified emulsions (Emulgel) of Turmeric by using high molecular weight water soluble polymer Carbapol 934 and Carbopol 940. This Carbapol possesses very high viscosity, transparency, film forming properties at low concentration and reported to be useful in formation of gel with an objective to increase transparency and spreadability. All the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. The influence of the type of gelling agent on the drug release from the prepared emulgels was investigated and carbopol 934 showed good results not only in the drug release but also in physical evaluation parameters. From the drug release studies, F3 formulation showed 90.05% drug release in 6 h with good clarity and physical appearance and viscosity. Stability studies showed that the physical appearance, rheological study, in vitro drug release, and anti-inflammatory activity in all the prepared emulgel remained unchanged upon storage for 3 months. It was finally concluded that the formulation F3 with 1%w/w Carbopol 934 was found to be more promising formulations as it shows better physicochemical characteristics and anti inflammatory activity compared to other formulations.

Keywords

Turmeric, Emulgel, Topical, Anti-inflammatory activity

Full Text

References