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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44499

GESTATIONAL EXPOSURE TO ANTIDEPRESSANTS AND THEIR IMPACT ON THE NEURODEVELOPMENT AND PHYSICAL OUTCOMES IN THE OFFSPRING: A POPULATION-BASED COHORT STUDY

Pallavi singh, Dr P Geetha

Abstract

This study is aimed to study the gestational exposure to antidepressants and their impact on the neurodevelopment and physical outcomes in the offspring. The objective of the study is to General and medical information, as well as estimations of the level of mental distress will be obtained by standardized questionnaires. To accesses the prevalence of antidepressant associated symptoms in new born Assessment of Neurodevelopment and physical outcomes of child by using standardized questionnaires namely Early Motor Questionnaire (EMQ) for age group of children from 1-6 years which is parent questionnaire were circulated to control (n-250) and case (n-250). Physical outcomes like congenital malformations, birth weight, seizures, hospitalization, preterm delivery, respiratory distress of children were collected from retrospective data maintained during gestational period and child birth which were collected from clinic. Results and discussion: In pregnant women baseline risk of congenital malformations is about 3%, and of cardiovascular malformations, 1%. Rates of spontaneous abortion vary in general population between 15 and 20%. Pre-term births occur in approximately 13% of pregnancies, we found relation between exposure of prenatal antidepressants and occurrence of physical outcomes like low birth weight, miscarriages, hospitalization, preterm births, respiratory distress, seizures, gastrointestinal problems, improper. Neurodevelopment abnormalities were found in the case as a result of seratogenic toxicity and withdrawal symptoms of antidepressants in offspring. During follow up of study the children’s Gross motor skills, Fine motor skills, Perception action and mental cognition were analyzed using EMQ questionnaires and their scores were compared with control and significant result was found. Conlusion: Based on observations made in this study, neonatal outcomes were observed; the withdrawal symptoms experienced by the child were transient and also alter lifestyle.

Keywords

This study is aimed to study the gestational exposure to antidepressants

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