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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44459

Evaluation the levels of atrial natriuretic peptide and some Biochemical Parameters in Patients with Hypertension

Fatima Abbas Mohammed, Ammar Lateef Hussein

Abstract

Background: Hypertension has been identified by WHO as one of the most significant risk factors for morbidity and mortality worldwide and is responsible for the deaths of approximately nine million people annually Aim of the study: The aim of this study was to evaluate the relation of serum atrial natriuretic and other biochemical parameters with hypertension and possibility of use these parameters in development of hypertension Material and Methods: The current study is case control study conducted on 90 Iraqi participants (25- 85years) during the period between 10th of January to 10th of April 2022, participants from in Kirkuk city.The study included 60 patients previously diagnosed with hypertension whose from both sexes whose age were between 36 and 85 year. Hypertension, defined as a systolic blood pressure greater than 130 mmHg or a diastolic blood pressure greater than 80 mmHg or are taking medication for hypertension. These patients included when attended to Kirkuk General Hospital. The study also included 30 healthy individuals with same age range and from both sexes who apparently haven’t any chronic diseases.Blood samples collected by vein puncture for determination of cholesterol, triglyceride (TG), high density lipoprotein- cholesterol (HDL-C), low density lipoprotein(LDL),very low density lipoprotein by bio chemical colorimetric methods and determination of human ANP by enzyme-linked immunosorbent assay (ELISA). Results: The study showed that the lowest mean of ANP was observed in patients with hypertension (31.57 pg/ml) and the highest mean was in the healthy control group (53.35 pg/ml), the difference was significant at P. value: 0.001.The also study showed that the highest mean of cholesterol was detected in patients with hypertension (178.46 mg/dl) as compared with healthy control group (166 mg/dl), the difference was significant at P. value: 0.017. The highest mean of triglyceride was detected in patients with hypertension (169.01 mg/dl) as compared with healthy control group (124.1 mg/dl), the difference was significant at P. value: 0.015. The highest mean of VLDL was detected in patients with hypertension (33.8 mg/dl) as compared with healthy control group (24.8 mg/dl), the difference was significant at P. value: 0.015. The study also showed a significant positive correlation of ANP levels with each of cholesterol, VLDL and triglyceride.

Keywords

Hypertension; ANP; Lipid profile; Kirkuk; Blood pressure

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