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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44451

Effect of Dexmedetomedine on Oxidative Stress Accompanying Trumatic Brain Injury

Omyma Shehata Mohamed1, Mohab Mohamed Naguib2, Mahmoud Mohamed Mousa3, Abd Elrahman Hassan Abd Elaziz4*, Ahmed Korany Mohamed5

Abstract

Traumatic brain injury (TBI) is a leading cause of death and disability allover the world. It is caused by a blow to the head from blunt or penetrating trauma (1). The burden of TBI is more prominent in Developing Countries which face a higher prevelance of risk factors for causes of TBI and have inadequately prepared health systems (2). The major goals of anesthesia during craniotomy in patients with traumatic brain injury (TBI) are maintenance of hemodynamic stability, optimal cerebral perfusion pressure, lowering of ICP, and providing a relaxed brain (3). Although both inhalational and intravenous anesthetics are commonly employed, there is no clear consensus on which technique is better for the anesthetic management TBI (3). Oxidative stress is a disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defenses (4). Oxidative stress may contribute to many pathophysiological changes that occur after traumatic brain injury (4).

Keywords

Oxidative Stress, Dexmedetomedine, Traumatic Brain Injury.

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