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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44448

Neutrophil to Lymphocyte Ratio as a Marker of Disease Activity in Patients with KneeOsteoarthritis

Galala Mohamed Amin Qader1*, Dashty Abbas Albustany2

Abstract

Background:Knee osteoarthritis is a debilitating inflammatory disease that affects the quality of life of people, especially the elderly. One of the markers is the neutrophil lymphocyte ratio (NLR) which can be used to monitor disease activity and determine inflammatory disease progression and treatment effectiveness. Therefore, this study was performed to evaluate the neutrophils lymphocytes ratio as an marker of disease activity in patients with osteoarthritis of the knee. Method: This study is a cross-sectional study that was performed in October 2021 to April 2022 on 100 patients with knee osteoarthritis referred to the Rheumatology Clinic of Rizgari Teaching Hospital in Erbil. Data were collected using a questionnaire that included three sections: demographics, medical history, and test results for inflammatory markers. Descriptive and linear regression tests were used to analyze the data. Result: Examination of patients' clinical status showed that 99 (99%) people have knee pain, In terms of limb involvement and limb pain, 22% reported pain in the right leg. Also 22% reported pain in the left leg and 56% reported pain and involvement in both legs. The mean of NLR = 2.045 (1.373) CI 95%, 1.770 - 2.31 was obtained. The results of linear regression the relationship between NLR and pain intensity in patients has been reported directly. Conclusion: According to the findings of the present study, it seems that the neutrophil to lymphocyte ratio (NLR) can be used as a marker in assessing the severity and activity of osteoarthritis (OA).

Keywords

Knee Osteoarthritis, Neutrophil to Lymphocyte Ratio, Disease Activity, inflammatory Markers.

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