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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44444

Gene Polymorphisms of Receptors for Advanced Glycation End Products (RAGE) in Association with Incidence of Colorectal Cancer (CRC) among Iraqi Patients

Omer Salah Al-Doori1*, Shatha H. Ali2

Abstract

Introduction: Cancer is a well-known public health problem and is a major cause of death worldwide. Colorectal Cancer (CRC), is the most common malignant cancer. Worldwide, (CRC), is the most common cancer in the gastrointestinal tract, and represents 13% of all malignant tumors, affecting men as women, in the same manner, in developed and undeveloped countries.In Iraq, CRC has increased in the last 10 years, and become the leading cause of about 10% of cancer mortality. An increase in the concentration of end products of the advanced glycation is thought to induce a rise in RAGE receptor expression. Their presence causes continual cell stimulation and, as a result, irreparable tissue damage. Diabetic problems, immune reactions, and neoplastic cell proliferation are all examples of such processes in pathological situations.RAGE are presented with several gene polymorphisms, among the commonest gene polymorphism for RAGE are rs1800625, rs1800624, rs2070600, and rs184003, which may contribute to many illness conditions. Methods: One hundred–forty unrelated participants, males, and females, 90 of them are CRC patients, besides 50 apparently healthy subjects, who were age & sex matched that of the patients, to serve as controls.Blood Specimens had been collected from each patient and healthy control subjects, whole blood has been placed into a tube containing EDTA for DNA extraction and genetic study. Results: significant variationswere detectedfrom rs1800624, rs2070600, and rs184003 polymorphisms between patients and controls, but not with rs1800625 gene, yet all studied polymorphisms show no correlation between each other. Conclusion: RAGE polymorphisms (rs1800624), (rs2070600), and (rs184003) have shown to be associated with CRC unlike (rs1800625), which had shown a non-significant differencebetween Iraqipatient and control groups in the current study. Recommendation: Large scale genetic studies including RAGE gene polymorphisms to confirm the association of each gene polymorphismindividually with CRC and other diseases.

Keywords

CRC, RAGE gene polymorphisms, rs1800624, rs2070600, rs1800624,rs1800625.

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