Home About Login Current Archives Announcements Editorial Board
Submit Now For Authors Call for Submissions Statistics Contact
Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44443

Correlation between High-Mobility Group Box 1 (HMGB1) and Carcinoembryonic Antigen CEA in Iraqi Colorectal Cancer Patients

Omer Salah Al-Doori1*, Shatha H. Ali2


Introduction:Cancer is a well-known public health problem, and it is a major cause of death worldwide. Colorectal Cancer (CRC), is the most common malignant cancer in the gastrointestinal tract and Carcinoembryonic antigen (CEA) is the most common diagnostic biomarker used in (CRC) and most of the gastric tumors which is used to identify/monitor or detect the type of tumoras it’s used as a predictive and prognostic biomarker.High mobility group box protein-1 (HMGB1) proteins are one of the majorReceptors for Advanced Glycation End Products(RAGE)-ligands that contribute to inflammation consequences and an increased release of RAGE ligands, can play multiple roles in promoting the pathogenesis of (CRC), as it had been heavily implicated in the pathogenesis of (CRC).The research aims to detectthe possible relationship between CEA and HMGB1 in (CRC). Methods:One hundred –forty unrelated participants, males and females, 90 of theme are CRC patients, besides 50 apparently healthy subjects, age & sex matching that of the patients, to serve as controls. The serum was obtained from each individual and stored frozen at -20 C ̊ until the time of analysis, using specific ELISA kits for (HMGB1 and CEA), to determine their serum levels. Results:Highly significant differences in serum levels (P=<0.0001) were obtained from both parameters, (85.33±2.86pg/ml)for CEA and (1.14±0.05ng/ml) for HMGB1 by the control group compared with (171.16±4.59 pg/ml) and (2.72±0.08ng/ml) for CEA and HMGB1respectively in patients’ group.Also, a high sensitivity and specificity for both parameters had been detected, with a remarkable criterion accuracy (cutoff point) and positive correlation between those parameters in the current study. Conclusion:Thecurrent study concludes that HMGB1 level shows similar sensitivity and specificity with a criterion accuracy (cutoff point) as forCEA and could be used for routine monitoring, diagnosis, and follow the prognosis for CRC as well as CEA does, with better diagnostic accuracy comparing with CEA, especially for early-stage CRC. Recommendation: current study suggests using HMGB1 as a diagnostic parameter for CRC.


Cancer, CRC, CEA, HMGB1.

Full Text