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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44411

Diagnostic value of Serum Apelin Levels in Children with Heart Failure

Ahmed N.Gamil, Magdy MK Mahmoud, Moustafa Abd ElRheem, Mohammed Abdelrazek Abdelhakeem

Abstract

neuroendocrine activation is typically found in patients with ،Apelin is an endogenous inotrope congestive heart failure (CHF). This activation includes, among others, the natriuretic peptides, which are secreted by the cardiac atria and ventricles as a response to volume and/or pressure overload. ANP has a vasodilator effect and may partly counteract the adverse effects of sympathetic activation in patients with HF. Objective: We aimed to evaluate the prognostic value of aplein level in children with HF and its correlations with ANP. Methods: Forty children with HF were included as a patient group. Twenty five healthy children matched for age, sex, and weight served as a control group. Chest X-ray, electrocardiogram (ECG), echocardiography, and laboratory investigations such as complete blood count, c-reactive protein, and serum apelin levels were performed for all included children at admission. Results: Serum apelin level was significantly decreased in patients with HF at admission than healthy control group and this decrease went with advanced stage of HF. Serum ANP levels were significantly increased in patients with unfavorable prognosis than those with favorable prognosis. Conclusion: Serum apelin level has a good predictive value for adverse outcome in children with HF.

Keywords

Serum apelin ·ANP · Heart failure

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