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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44416

Efficacy Of Photobiomodulation Versus Its Combination with Plasma Rich Growth Factors or Minoxidil in Management of Androgenetic Alopecia

MahaRafea Abo Eitta, Ahmed Sadek, Noha Abdelaziz Amer, Nevien Samy , Noha Abdallah


Background: Androgenetic alopecia (AGA) is considered the utmost familiar etiology of hair loss in males. Topical minoxidil and more recently low-level light therapy (LLLT) or photobiomodulation in addition to plasma rich growth factors (PRGFs) known also as platelets rich plasma (PRP) therapy have been used in the management of AGA. Objectives: To evaluate which is more effective for the managementof androgenetic alopecia: LLLT alone, LLLT with PRGFs or with topical minoxidil. Materials and methods: Forty-five patients having androgenetic alopecia were divided randomly into 3 equal groups: (Group A) were subjected to PRP therapy plus LLLT, (Group B) were subjected to minoxidil therapy plus LLLT and (Group C) were subjected to LLLT alone. All groups were treated for 3 months and were followed up for another 3 months after stopping treatment. Efficacy was assessed using global photography, folliscopic pictures analysis and patient satisfaction score after a standardized hair growth inquiry form. Results: By the end of the sixth month, (Group A) was found to have the best statistically significant improvement followed by (Group B) then (Group C).This was clearly obvious in global photography, folliscopic analysis, and patient’s satisfaction. Conclusion: Combination of PRP with LLLT is better than its combination with minoxidil or as monotherapy in the managementof AGA.


androgenetic alopecia, Platelets-rich plasma, Minoxidil, Low-level laser therapy

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