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Home > Archives > Volume 20, No 8 (2022) > Article

DOI: 10.14704/nq.2022.20.8.NQ44082

Cytoprotective Effect ofDaidzein, Naringenin, and Icariin against Cisplatin Induced Neurotoxicity in Mice

Arvind S Jadon, Manoj Sharma

Abstract

Introduction: Cisplatin is an effective chemotherapeutic drug with significant dose-limiting neurotoxicity that causes peripheral neuropathy. Although it is hypothesised that DNA platinum adduct production is responsible for both its cytotoxicity in cancer cells and adverseefects in neurons, downstream mechanisms that cause distal axonal degeneration are still unknown. Objective:The cytoprotective efficacy of Daidzein, Naringenin, and Icariin was investigated against Cisplatin-induced neurotoxicity in female Swiss mice during this work. Methods: All animals were divided into two sets i.e. pre-cisplatin (BA)and post-cisplatin (AA) administration and treated with Daidzein, Naringenin, and Icariin. Nephrotoxicity was assessed by body weight and biochemical parameters i.e. ALT, lipid peroxidation (MDA level) and Glutathione (GSH). Results:During this study body weight of the experimental animal changed by 5% maximum observed in both sets. Biochemical brain showed that pre-treated and post-treated with Icariin groups were most effectiveagainst cisplatin induced neurotoxicity as compare to naringenin and daidzein. These findings are also confirmed by histopathology. Conclusion: The study has proven that pre-treatment with flavonoids was found more effective against cisplatin-induced cytotoxicity as compared to post-treatment.

Keywords

Cytoprotective, Flavonoids, Cisplatin Cytotoxicity, neurotoxicity.

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