DOI: 10.14704/nq.2022.20.7.NQ33151

Synthesis, characterization, proposed mechanism, QSAR Studies and inhibition of Platelet aggregation of Novel 2-[(substituted benzylidene) imino]-5-(p-acetamidophenyl)-1,3,4 oxadiazole

Kashid Girish *, Singh Santosh Kumar, Saravanan Janardhan, Patil Prashant

Abstract

Oxadiazole derivatives are a significant class of heterocyclic compounds with a wide range of biological activity described for them. Additionally, the oxadiazole nucleus holds a significant position in the world of antioxidants. In order to create novel oxadiazole derivatives with a variety of substitutions and heterocyclic rings in the same framework, we were motivated by the observations mentioned above. Here, we provide the results of the novel title compounds' synthesis, antioxidant screening, and QSAR analyses. Specifically, 2-[(substituted benzylidene) imino]-5-(p-acetamidophenyl)-1,3,4 oxadiazole was synthesised, tested for antioxidant activity, and subjected to QSAR analyses. New entities all produce good yields and outcomes. The compounds containing both electron donating and electron withdrawing groups on the aldehydic phenyl ring were shown to influence antioxidant activity, according to the results of the study. Among all the substances examined GS-8i-d, GS-8i-g, GS-8i-l, GS-8i-m, had good% inhibition and were discovered to be more important substances. In order to anticipate the effects of oxadiazole derivatives, 2D and 3D-QSAR models were developed. Hydrophobicity's importance as a 3D feature was established, and it was discovered that electrostatic and steric effects also support inhibition of Platelet aggregation.

Keywords

Oxadiazole, Inhibition of Platelet aggregation, 2D QSAR & 3D QSAR

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