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Home > Archives > Volume 20, No 7 (2022) > Article

DOI: 10.14704/nq.2022.20.7.NQ33017

Study of Pentraxin 3 protein (PTX3) as a Biomarker in the Serum of Iraqi Patients with Rheumatoid Arthritis

Mihad M. Hamid , Bushra F. Hassan , Ali Hussein Al-Hafidh . Samer abdulhassn muhi

Abstract

Rheumatoid arthritis, also known simply as RA, is a form of the autoimmune disease arthritis that manifests itself in the joints as pain, swelling, stiffness, and a loss of function. Although it can occur in any joint, it is most frequently seen in the fingers and wrists. The objective of this study was to measure PTX3, CRP, I.R, Insulin .F.G, and Lipid profiles in patients with Rheumatoid arthritis. The current study comprised a total of 120 participants, who were separated into two groups. Group1 contained 70 Rheumatoid arthritis patients, and group2 controls 50; the samples were extracted from women and man, the levels of PTX3, CRP, I.R .F.G, Insulin, Cholesterol, TG, VLDL, LDL, and HDL were evaluated. The levels of PTX3 and Insulin were determined using an enzyme-linked immunosorbent assay (ELISA), and the stories of FBG, Cholesterol, TG, VLDL, LDL, and HDL were assayed using a spectrophotometer. The result of PTX3 shows a high significant change among two groups' patients and control. Serum levels of Triglyceride, Cholesterol, HDL, VLDL and CRP show the significant change between two groups' patient and control. Systole , Diastole, and LDL values have non-significant change in their levels in RA patients. Insulin, F.G, and I.R values have a significant change in their levels in patients RA.

Keywords

According to the presented results PTX3, CRP, I.R .F.G, Insulin, T.G, Cholesterol, VLDL, and HDL do affect by RA patient. Systole, Diastole, and LDL do not affect by RA patient

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