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Home > Archives > Volume 20, No 5 (2022) > Article

DOI: 10.14704/nq.2022.20.5.NQ22663

Role of Triphasic Computed Tomography in Hepatitis C Patients after Treatment by Direct Acting Antivirals to Detect Hepatocellular Carcinoma

Heba Fathy Tantawy, Stefany Adel AbdElMalak, and Maha Ibrahim Metwally

Abstract

Background: Hepatocellular carcinoma (HCC) is one of the most prevalent neoplasms worldwide which is considered as significant causing of mortality over the past 2 decades. HCC usually progresses in cases with chronic liver diseases, often related to hepatitis C virus (HCV) infection. The goal of the study was to detect of the risk of occurrence of Hepatocellular carcinoma in HCV positive patients after treatment by direct acting antivirals (DAA). Results: The higher patient age, higher AFP, also the longer duration since last dose of treatment, liver cirrhosis and liver size were significantly correlated with HCC positive cases. By applying multivariate logistic regression on the statistically significant predictors in univariance for HCC development, age above 57 years and AFP >12.5ng\ml were the independent predictors for HCC development. Conclusion: Triphasic CT is considered the ideal screening examination for the entire abdomen and pelvis. It is considered the most diagnostic CT examination for hepatic tumors such as HCC.

Keywords

HCC, HCV, Triphasic CT, Hepatocellular carcinoma, Computed tomography, serum alpha-fetoprotein.

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