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Home > Archives > Volume 20, No 5 (2022) > Article

DOI: 10.14704/nq.2022.20.5.NQ22222

Brassica Oleracea Alcoholic Extract on Vitamin D3 Level and Some Blood Biochemical Parameters in Albino Male Rats Treated with Paracetamol

Wafaa Mohammed Ridha Abdel Rasoul, Dr. Saher Mahmood Jwad

Abstract

This work was carried out in labs of University of Kufa, beginning 1/10/2021 to 1/12/2021, and was conducted by following up on (28) albino male rats of the Sprague Dawley strain at the age of three months to determine the efficiency of the alcoholic extract of Brassica oleracea flowers in the prevention of the paracetamol-induced hepatotoxicity and nephrotoxicity, the weights of rats ranged between 216-246, and then alienated into four assembly s for every assembly of 7 rats, where the first assembly was a control orally dosed with tap water, and the second assembly was salted with paracetamol concentration 2000 mg / kg orally, either the third assembly was certain the alcoholic extract of Brassica oleracea flowers at a concentration of 500 mg/kg and the drug was certain at a concentration of 2000 mg/kg orally, while the last assembly was administrated with the alcoholic extract only through the mouth. Furthermore, the treatment continued for a period of (60) days, in the morning (at half past eight), once a day. The study included evaluation of biochemical parameters such as flats of vitamin D3, calcium, phosphate, creatinine, urea. The conclusion is the alcoholic extract of broccoli flowers has shown a protective role against the pathological effects of the drug, and this may be explained by its active chemical antioxidant components.

Keywords

Alcoholic Extract of Brassica Oleracea Flowers, Paracetamol, D3, Biochemical Parameters

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