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Home > Archives > Volume 19, No 12 (2021) > Article

DOI: 10.14704/nq.2021.19.12.NQ21190

Brain Tissues Affection After Oral Tramadol: An Experiment Study

Emad Hazim Mhmood


Tramadol may lead to the accumulation of toxic components in the body. This study aims to detect the toxic effect of tramadol on brain tissues. The clinical experiment was carried out at the Department of Neurosurgery, Ibn Sina Hospital. Ten rats of both sex weighing (180-300 g) were selected from the veterinary house. Brain tissues were immediately removed and put into 10% neutral buffer formalin for fixation, then stained with Hematoxylin-Eosin stain. A significant decrease in the brain weight in rats when given the tramadol in dose 50 mg/ kg. Changes included a mild degree of tissue injury in the cerebral cortex, increase in vacuolar degeneration, with atrophy and degeneration of neurons. There are toxic effects when tramadol describes for a long time on the brain tissues.


Tramadol, Brain Trauma, Brain tissues, Glial Cell, Neuron.

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