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Home > Archives > Volume 20, No 17 (2022) > Article

DOI: 10.14704/NQ.2022.20.17.NQ88008

Formulation and Evaluation of Solid Lipid Nanoparticles of Wheatgrass (Triticum Aestivum) Extract

Neha Minocha, Nidhi Sharma, Parijat Pandey, Sangita Saini

Abstract

Objective: The development of nanoparticles for drug delivery is gaining popularity swiftly, especially for anticancer drugs as it holds the possibility of addressing a number of issues with these medications. The rationale of current research-work was to formulate wheatgrass loaded solid lipid nanoparticles by means of hothomogenization method. Specifically, we investigated the effects of chemical that stabilizes the surface and time for sonication on the amount of wheatgrass extract that maximally and efficiently entrapped in solid lipid nanoparticles. Method: Under the methodology section, three factors were assessed i.e., concentration of sodium alginate (2-10 mg/ml), concentration of chitosan (2.5-12.5 mg/ml) and time required for sonication (5 - 20 min). Different batches of solid lipid nanoparticles, were evaluated for their size of particles in formulation, entrapment efficiency, polydispersity index, percentage yield and loading capacity. The optimized batch was characterized for its compatibility studies by Fourier Transform Infrared Spectroscopy (FTIR), zeta potential for stability and Scanning Electron Microscopy for morphology. Results: Characterization and evaluation of prepared SLNs showed that batch NM-3 (formulated using chitosan and sodium alginate having amount of 7.5mg and 5mg, respectively while sonicating the formulation for 15 minutes) having a maximum entrapment efficiency 49.75±0.13 % (w/w), a maximum drug loading capacity 54.78±0.19 % (w/w) observe smallest particle size of 375.5nm among all fifteen batches (NM-1 to NM-15). FTIR spectra interpretation of NM-3 indicated the compatibility of drug and the polymer as, comparison of the interpretations for both the FTIR showed no significant changes. Conclusion: Wheatgrass loaded nanoparticles are developed by analyzing the nano-effects caused by biologically acceptable and compatible chitosan and the time required for sonication

Keywords

Wheatgrass, Solid lipid nanoparticles, Chitosan, Hot homogenization, FTIR, Characterization, Nanoparticles.

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