DOI: 10.14704/nq.2015.13.2.842

Cytoskeleton and Consciousness: An Evolutionary Based Review

Contzen Pereira


The fields of quantum biology and physics are now starting to unite to solve the mysteries associated with the field of evolutionary biology. One such question is the origination and propagation of consciousness which has always been ambiguous and in order to understand this concept, many theories have been proposed by several philosophers and scientists. This review paper agrees with the idea, that evolution is not a random process but hypothesizes, that its succession was managed by the expanding level of consciousness due to cell division and cell differentiation. Several theories propose that the cytoskeleton and its proteins are promoters for consciousness in the brain, which propagates by means of super-conductance. A better correlation of cytoskeletal evolution and consciousness could help solve the enigma of the origination, propagation and existence of consciousness. This review is a compilation of theories, evidences and scientific studies which intends to bring an association between propagation of consciousness and the evolution of the cytoskeleton and its proteins.


Cytoskeleton; consciousness; evolution; tubulin; microtubules

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Bork P, Sander C and Valencia A. An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins. Proc Natl Acad Sci USA 1992; 89:7290-7294.

Briegel A, Dias DP, Li Z, Jensen RB, Frangakis AS and Jensen GJ. Multiple large filament bundles observed in Caulobacter crescentus by electron cryotomography. Mol Microbiol 2006; 62 (1): 5–14.

Brown JR and Doolittle WF. Archaea and the prokaryoteto- eukaryote transition. Micro Mol Biol Rev 1997; 61: 456–502.

Davey ME and O'toole GA. Microbial Biofilms: from Ecology to Molecular Genetics. Microbiol Mol Biol Rev 2000; 64(4): 847–867.

Dayhoff JE, Hameroff S, Lahoz-Beltra R and Swenberg CE. Cytoskeletal involvement in neuronal learning: a review. Eur Biophys J 1994; 23:79-93.

de Boer P, Crossley R, Rothfield L. The essential bacterial cell division protein FtsZ is a GTPase. Nature (London) 1992; 359:254-256.

Denton DA. The Primordial Emotions: The Dawning of Consciousness Oxford Univ Press, Oxford, UK. 2006.

Doolittle WF. Some aspects of the biology of cells and their possible evolutionary significance, in Evolution of Microbial Life (Roberts, D.M. et al., eds). Cambridge University Press, 1996; pp. 1–22,

Edelman G. Wider than the sky: The phenomenal gift of consciousness: Yale Univ Pr. New Haven, CN, USA. 2004.

Edlind TD, Li J, Visvesvara GS, Vodkin MH, McLaughlin GL and Katiyar SK. Phylogenetic analysis of b-tubulin sequences from amitochondrial protozoa. Mol Phylogent Evol 1996; 5:359-367.

El Albani A, Bengtson S, Canfield DE, Bekker A, Macchiarelli R, Mazurier A, Hammarlund EU, Boulvais P, Dupuy JJ, Fontaine C. et al. Large colonial organisms with coordinated growth in oxygenated environments 2.1 Gyr ago. Nature 2010; 466:100-104.

Erickson HP. FtsZ, a prokaryotic homolog of tubulin? Cell 1995; 80: 367–370.

Fröhlich H. Long-range coherence and energy storage in biological systems. Int J Quantum Chem 1968; 2:641-649.

Fröhlich H. Long range coherence and the actions of enzymes. Nature 1970; 228:1093.

Fröhlich H. The extraordinary dielectric properties of biological materials and the action of enzymes. Proc Natl Acad Sci 1975; 72:4211-4215.

Gelber B. Retention in Paramecium aurelia. J Comp Physiol Psych 1958; 51:110-115.

Golding GB and Gupta RS. Protein-based phylogenies support a chimeric origin for the eukaryotic genome, Mol Biol Evol 1995; 12: 1–6.

Gunning PW, Ghoshdastider U, Whitaker S, Popp D, Robinson RC. The evolution of compositionally and functionally distinct actin filaments. J Cell Sci 2015. doi: 10.1242/jcs.165563.

Hameroff S. Quantum computation in brain microtubules? The Penrose-Hameroff Orch OR model of consciousness. Phil Trans R Soc Lond A 1998a; 356: 1869-1896.

Hameroff S. Quantum Computation in Brain Microtubules? The Penrose-Hameroff "Orch Or" Model of Consciousness. Phil Tran Math Phys Eng Sci 1998b; 356(1743): 1869-1896.

Hameroff SR and Penrose R. Orchestrated reduction of quantum coherence in brain microtubules: A model for consciousness. In: Toward a Science of Consciousness The First Tucson Discussions and Debates, S.R. Hameroff, A. Kaszniak and A.C. Scott (eds.), MIT Press. 1996.

Hameroff S and Penrose R. Consciousness in the universe. A review of the ‘Orch OR’ theory. Phys Life Rev 2014; 11: 39–78.

Hameroff SR and Watt RC. Information processing in microtubules. J Theor Biol 1982; 98: 549-561.

Jékely G. Origin and Evolution of the Self-Organizing Cytoskeleton in the Network of Eukaryotic Organelles. Cold Spring Harb Perspect Biol 2014; 2: 6(9).

Jenkins C, Samudrala R, Anderson I, Hedlund BP, Petroni G, Michailova N, Pinel N, Overbeek R, Rosati G and Staley JT. Genes for the cytoskeletal protein tubulin in the bacterial genus Prosthecobacter. PNAS 2002; 99(26): 17049–17054.

Jibu M, Pribram KH and Yasue K.From conscious experience to memory storage and retrieval: The role of quantum brain dynamics and Bose condensation of evansecent photons. Int J Mod Physics B 1996; (13&14):1735-1754.

Katiyar SK and Edlind TD. Beta-tubulin genes of Trichomonas vaginalis. Mol Biochem Parasitol 1994; 64:33- 42.

Keeling PJ and Doolittle WF. Alpha-tubulin from early diverging eukaryotic lineages and the evolution of the tubulin family. Mol Biol Evol, 1996; 13 (10): 1297 – 1305.

King CC. Cosmological Foundations of Consciousness. J Cosmo 2011; 14.

Kirk-Mason KE, Turner MJ and Chakraborty FR. Cloning and sequence of beta-tubulin cDNA from Giardia lamblia. Nucleic Acids Res 1988; 16:2733.

Koch C. The Quest for Consciousness. Englewood CO: Roberts & Company, 2004.

Kutschera U and Niklas KJ. Endosymbiosis, cell evolution, and speciation. Theory Biosci 2005; 124:1–24.

Lai EY, Remillard SI and Fulton C. The alphatubulin gene family expressed during cell differentiation in Nuegleria gruberi. J Cell Biol 1988; 106:2035-2046.

Lane N and Martin WF. The Origin of Membrane Bioenergetics. Cell 2012; 151: 1406–1416.

Low P. Consciousness in human and non-human animals. The Francis Crick Memorial Conference. Eds Panksepp J, et al. (Cambridge, UK). 2012. Available at

http:// Accessed April 10, 2015.

Mans BJ, Anantharaman V, Aravind L and Koonin EV. Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex. Cell Cycle 2004; 3: 1612–1637.

Margolin W. FtsZ and the division of prokaryotic cells and organelles. Nat Rev Mol Cell Biol 2005; 6:862–871.

McNamara KJ and Awramik SM. Stromatolites: a key to understanding the early evolution of life. Sci Prog 1992; 76: 345-364.

Michie KA and Löwe J. Dynamic filaments of the bacterial cytoskeleton. Annu Rev Biochem 2006; 75: 467–92.

Miller MB and Bassler BL. Quorum sensing in bacteria. Annu Rev Microbiol 2001; 55 (1): 165–99.

Mitchell ED and Staretz R.The Quantum Hologram and the Nature of Consciousness. J Cosmo 2011; 14.

Mukherjee A, Dai K and Lutkenhaus J. Escherichia coli cell division protein FtsZ is a guanine nucleotide binding protein. Proc Natl Acad Sci USA 1993; 90:1053-1057.

Nogales E, Wolf SG and Downing KH. Structure of the alpha beta tubulin dimer by electron crystallography. Nature 1998a; 391:199–203.

Nogales E, Downing KH, Amos LA and Löwe J.Tubulin and FtsZ form a distinct family of GTPases. Nat Struct Biol 1998b; 5: 451–458.

Petroni G, Spring S, Schleifer K, Verni F and Rosati G. Defensive extrusive ectosymbionts of Euplotidium (Ciliophora) that contain microtubule-like structures are bacteria related to Verrucomicrobia. PNAS 2000; 97(4): 1813–1817.

Pilhofer M, Ladinsky MS, McDowall AW, Petroni G and Jensen GJ. Microtubules in Bacteria: Ancient Tubulins Build a Five-Protofilament Homolog of the Eukaryotic Cytoskeleton. PLoS Biol 2011; 9(12).

Pribram K. Holographic Brain. In the Omni Interviews, (Ed.) P. Weintraub, New York: Ticknor & Fields, 1982; pp.33-34.

Pühler G, Leffers H, Gropp F, Palm P, Klenk HP, Lottspeich F, Garrett RA and Zillig W. Archaebacterial DNA-dependent RNA polymerases testify to the evolution of the eukaryotic nuclear genome. Proc Natl Acad Sci USA 1989; 86: 4569–4573.

Rasmussen S, Karampurwala H, Vaidyanath R, Jensen KS and Hameroff S. Computational connectionism within neurons: A model of cytoskeletal automata subserving neural networks. Physica D 1990; 42:428-449.

RayChaudhuri D and Park JT. Escherichia coli cell-division gene ftsZ encodes a novel GTP-binding protein. Nature 1992; 359:251-254.

Reinis S, Holub RF and Smrz P. A quantum hypothesis of brain function and consciousness. Ceskoslovenska fyziologie 2005; 54; 26 - 31.

Rosati G, Lenz, P and Verni F. Epixenosomes, peculiar epibionts of the ciliated protozoon Euplotidium itoi: what kind of organisms are they? Micron 1993; 24, 465–471.

Russell SJ and Norvig P. Ch. 26: Philosophical foundations. Artificial Intelligence: A Modern Approach. Prentice Hall, 2010.

Sahu S, Ghosh S, Ghosh B, Aswani K, Hirata K, Fujita D. et al. Atomic water channel controlling remarkable properties of a single brain microtubule: correlating single protein to its supra molecular assembly. Biosens Bioelectron 2013a; 47:141.

Sahu S, Ghosh S, Hirata K, Fujita D and Bandyopadhyay A. Multi level memory switching properties of a single brain microtubule. Appl Phys Lett 2013b; 102:123701.

Sanchez MA, Pea-i-Tie DA, Wirth D, Orozco E. Cloning, genomic organization and transcription of the Entamoeba histolytica alpha-tubulin-encoding gene. Gene 1994; 146:239-244.

Shih YL and Rothfield L. The bacterial cytoskeleton. Microbiol Mol Biol Rev 2006; 70 (3): 729–54.

Stossel TP. From signal to pseudopod. How cells control cytoplasmic actin assembly. J Biol Chem 1989; 264: 18261-18264.

Swanson JA and Taylor DL. Local and spatially coordinated movements in Dictyostelium discoideum amoebae during chemotaxis. Cell 1982; 28: 225-232.

Taylor DL and Condeelis JS. Cytoplasmic structure and contractility in amoeboid cells. Int Rev Cytol 1979; 56, 57-144.

Torday JS and Rehan VK. The Evolution of Cell Communication: The Road not Taken. Cell Comm Insights 2009; 2: 17–25.

Tuszynski J, Hameroff S, Sataric MV, Trpisova B and Nip MLA. Ferroelectric behavior in microtubule dipole lattices; implications for information processing, signaling and assembly/disassembly. J Theor Biol 1995; 174:371-380.

Varnum-Finney BJ, Voss E and Soll DR. Frequency and orientation of pseudopod formation of Dictyostelium discoideum amoebae chemotaxing in a spatial gradient: further evidence for a temporal mechanism. Cell Motil Cytoskel 1987; 8: 18-26.

Vaughan S, Wickstead B, Gull K and Addinall SG. Molecular evolution of FtsZ protein sequences encoded within the genomes of archaea, bacteria, and eukaryota. J Mol Evol 2004; 58:19–29.

Wickramasinghe C. The Biological Big Bang. Cosmology Science Publishers. Cambridge, 2011.

Wickstead B and Gull K. The evolution of the cytoskeleton. J Cell Biol 2011; 194 (4): 513–525.

Woese CR and Fox GE. Phylogenetic structure of the prokaryotic domain: the primary kingdoms. Proc Natl Acad Sci USA 1977; 74: 5088–5090.

Wu TM and Austin S. Bose condensation in biosystems. Phys Lett A 1977; 64:151–152, 1977.

Wu TM and Austin S. Coperative behavior in biological systems. Phys Lett A 1978; 65:74–76, 1978.

Wu TM and Austin S. Froehlich’s model of bose condensation in biological systems. J Biol Phys 1981; 9:97–107, 1981.

Zillig W. Comparative biochemistry of Archaea and Bacteria. Curr Opin Genet Dev 1991; 1: 544–551.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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