DOI: 10.14704/nq.2019.17.6.2189

Psychobiotics, as Promising Functional Food to Patients with Psychological Disorders: A Review on Mood Disorders, Sleep, and Cognition

Aydin Tabrizi1, Leila Khalili, Aziz Homayouni-Rad, Hadi Pourjafar, Parvin Dehghan, Fereshteh Ansari

Abstract


Objective: Manipulating the intestinal microbiota for the benefit of the mental health is a concept that has become widely acknowledged. Prebiotics, the nondigestible nutrients, can proliferate intrinsic beneficial gut bacteria, and so provide an alternative strategy for effectively altering the enteric ecosystem, and then brain function. This review summarizes findings from studies using prebiotics to improve mental health and psychological disorders.

Methods: Pub Med, Google Scholar, Scopus, and Science Direct databases were searched by using “prebiotics”, “psychological disorders”, “mood disorders”, “depression”, “anxiety”, “stress”, “sleep”, and “cognition” for searching the studies aiming the application of prebiotics and the beneficial effects of them in mental health and psychological disorders’ control and/or treatment.

Results: Prebiotic consumption improved psychological and biological measures of mental disorders such as depression, anxiety, and stress in individuals with mood disorder. Overall, the results show that, through modulating the gut microbiota composition, prebiotics can beneficially affect mental health, modulate psychological disorders, and improve cognitive function and sleep/wake cycle disruptions.

Discussion: Prebiotics can improve mental health, mood, and psychological function. Habitual diets rich in dietary prebiotics would be linked to reduced risk of developing symptoms of psychological disorders; however, additional studies are necessary.

Keywords


prebiotics, psychological disorders, mood, depression, anxiety, tress, sleep, cognition

Full Text:

PDF

References


Abdolhosseinzadeh E, Dehnad AR, Pourjafar H, Homayouni A, Ansari F. The production of probiotic Scallion Yogurt: Viability of Lactobacillus acidophilus freely and microencapsulated in the product. Carpathian Journal of Food Science & Technology 2018; 10(3): 72-80.

Best T, Kemps E, Bryan J. Saccharide effects on cognition and well-being in middle-aged adults: a randomized controlled trial. Developmental neuropsychology 2009; 35: 66-80.

Burokas A, Arboleya S, Moloney RD, Peterson VL, Murphy K, Clarke G, Stanton C, Dinan TG, Cryan JF. Targeting the microbiota-gut-brain axis: prebiotics have anxiolytic and antidepressant-like effects and reverse the impact of chronic stress in mice. Biological psychiatry 2017; 82: 472-487.

Canfora EE, van der Beek CM, Hermes GD, Goossens GH, Jocken JW, Holst JJ, van Eijk HM, Venema K, Smidt H, Zoetendal EG. Supplementation of diet with galacto-oligosaccharides increases bifidobacteria, but not insulin sensitivity, in obese prediabetic individuals. Gastroenterology 2017; 153: 87-97. e83.

Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of gastroenterology: quarterly publication of the Hellenic Society of Gastroenterology 2015; 28(2): 203–209.

Chen D, Yang X, Yang J, Lai G, Yong T, Tang X, Shuai O, Zhou G, Xie Y, Wu Q. Prebiotic effect of fructooligosaccharides from Morinda officinalis on Alzheimer’s disease in rodent models by targeting the microbiota-gut-brain axis. Frontiers in aging neuroscience 2017; 9: 403.

Chunchai T, Thunapong W, Yasom S, Wanchai K, Eaimworawuthikul S, Metzler G, Lungkaphin A, Pongchaidecha A, Sirilun S, Chaiyasut C. Decreased microglial activation through gut-brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese-insulin resistant rats. Journal of neuroinflammation 2018; 15(1): 11.

Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nature reviews neuroscience 2012; 13: 701.

De Palma G, Lynch MD, Lu J, Dang VT, Deng Y, Jury J, Umeh G, Miranda PM, Pastor MP, Sidani S. Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice. Science translational medicine 2017; 9: eaaf6397.

Dinan TG, Cryan JF. The microbiome-gut-brain axis in health and disease. Gastroenterology Clinics 2017; 46: 77-89.

Forsatkar MN, Nematollahi MA, Rafiee G, Farahmand H, Lawrence C. Effects of the prebiotic mannan-oligosaccharide on the stress response of feed deprived zebrafish (Danio rerio). Physiology & behavior 2017; 180: 70-77.

Forsythe P, Sudo N, Dinan T, Taylor VH, Bienenstock J. Mood and gut feelings. Brain, behavior, and immunity 2010; 24: 9-16.

Gagnon M, Savard P, Rivière A, LaPointe G, Roy D. Bioaccessible antioxidants in milk fermented by Bifidobacterium longum subsp. longum strains. BioMed research international 2015; http://dx.doi.org/10.1155/2015/169381.

Han HS, Jang J-H, Jang JH, Choi JS, Kim YJ, Lee C, Lim SH, Lee H-K, Lee J. Water extract of Triticum aestivum L. and its components demonstrate protective effect in a model of vascular dementia. Journal of medicinal food 2010; 13: 572-578.

Jia S, Lu Z, Gao Z, An J, Wu X, Li X, Dai X, Zheng Q, Sun Y. Chitosan oligosaccharides alleviate cognitive deficits in an amyloid-β1–42-induced rat model of Alzheimer's disease. International journal of biological macromolecules 2016; 83: 416-425.

Koh A, De Vadder F, Kovatcheva-Datchary P, Bäckhed F. From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 2016; 165: 1332-1345.

Lai S-T, Lim K-S, Low W-Y, Tang V. Positive psychological interventions for neurological disorders: a systematic review. The Clinical Neuropsychologist 2018; 1-29.

Mika A, Day HE, Martinez A, Rumian NL, Greenwood BN, Chichlowski M, Berg BM, Fleshner M. Early life diets with prebiotics and bioactive milk fractions attenuate the impact of stress on learned helplessness behaviours and alter gene expression within neural circuits important for stress resistance. European journal of neuroscience 2017; 45: 342-357.

Mikolajczyk RT, El Ansari W, Maxwell AE. Food consumption frequency and perceived stress and depressive symptoms among students in three European countries. Nutrition Journal 2009; 8: 31.

Organization WH. Depression and other common mental disorders: global health estimates. 2017. World Health Organization.

Pourjafar H, Noori N, Gandomi H, Basti AA, Ansari F. stability and efficiency of double-coated beads containing lactobacillus acidophilus obtained from the calcium alginate-chitosan and Eudragit S100 nanoparticles microencapsulation. International Journal of Probiotics & Prebiotics 2018; 13 (2/3): 77-84.

Rad AH, Akbarzadeh F, Mehrabany EV. Which are more important: Prebiotics or probiotics? Nutrition 2012; 28: 1196.

Réus G, Fries G, Stertz L, Badawy M, Passos I, Barichello T, Kapczinski F, Quevedo J. The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders. Neuroscience 2015; 300: 141-154.

Savignac HM, Couch Y, Stratford M, Bannerman DM, Tzortzis G, Anthony DC, Burnet PW. Prebiotic administration normalizes lipopolysaccharide (LPS)-induced anxiety and cortical 5-HT2A receptor and IL1-β levels in male mice. Brain, behavior, and immunity 2016; 52: 120-131.

Smith A, Sutherland D, Hewlett P. An investigation of the acute effects of oligofructose-enriched inulin on subjective wellbeing, mood and cognitive performance. Nutrients 2015; 7: 8887-8896.

Tarr AJ, Galley JD, Fisher SE, Chichlowski M, Berg BM, Bailey MT. The prebiotics 3′ Sialyllactose and 6′ Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut–brain axis. Brain, behavior, and immunity 2015; 50: 166-177.

Thompson RS, Roller R, Mika A, Greenwood BN, Knight R, Chichlowski M, Berg BM, Fleshner M. Dietary prebiotics and bioactive milk fractions improve NREM sleep, enhance REM sleep rebound and attenuate the stress-induced decrease in diurnal temperature and gut microbial alpha diversity. Frontiers in behavioral neuroscience 2017; 10: 240.

Vázquez E, Barranco A, Ramírez M, Gruart A, Delgado-García JM, Martínez-Lara E, Blanco S, Martín MJ, Castanys E, Buck R. Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents. The Journal of nutritional biochemistry 2015; 26: 455-465.

Wallace CJ, Milev R. The effects of probiotics on depressive symptoms in humans: a systematic review. Annals of general psychiatry 2017; 16: 14.

Wang T, Cai G, Qiu Y, Fei N, Zhang M, Pang X, Jia W, Cai S, Zhao L. Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers. The ISME journal 2012; 6: 320.


Supporting Agencies





| NeuroScience + QuantumPhysics> NeuroQuantology :: Copyright 2001-2019