DOI: 10.14704/nq.2018.16.12.1851

A Voxel-Based Morphometric Brain Study of Patients with Methamphetamine Dependency: A Case Controlled Study

Vahid Farnia, Firoozeh Farshchian, Nazanin Farshchian, Mostafa alikhani, Ramin Pormehr, Sanobar Golshani, Safora Salemi


Methamphetamine (MA) use has been an important health problem in Iran in recent decade. Previous studies have suggested brain structural abnormalities in MA users. Increasing knowledge about the MA induced structurally and functionally brain changes is important for better management of this disorder. The aim of the present study was to investigate the possible structural brain structural changes in MA dependent patients. This was a case-control study, which conducted in Farabi mental hospital in the west of Iran. Voxel-based-mor phometry (VBM) as a whole-brain technique for characterizing regional cerebral volume and tissue concentration differences in structural MRI was administered. We used VBM to assess regional brain differences in 25 MA dependent patients and 20 age, sex matched healthy controls. In MA dependent patients hippocam, parahippocamp, left frontal lobe, right frontal lobe, left temporal lobe, and right temporal lobe volumes were significantly lower than healthy control subjects (P< 0.05). Also caudate and amygdala volume in MA dependent patients were smaller than healthy subjects (P< 0.05). The brain volume reduction of MA dependent patients compared to control subjects may explain the prevalence of psychiatric disorders in these patients, and could help to provide therapeutic strategies for drug-induced brain injury.


Methamphetamine, Brain, Magnetic Resonance Imaging, Voxel-Based-Morphometry (VBM)

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Alam-Mehrjerdi Z, Abdollahi M, Higgs P, Dolan K. Drug use treatment and harm reduction programs in Iran: A unique model of health in the most populated Persian Gulf country. Asian J Psychiatr 2015; 16: 78-83.

Barros-Loscertales A, Garavan H, Bustamante JC, Ventura-Campos N, Llopis JJ, Belloch V, Avila C. Reduced striatal volume in cocaine-dependent patients. Neuroimage 2011; 56(3): 1021-1026.

Chang L, Cloak C, Patterson K, Grob C, Miller EN, Ernst T. Enlarged striatum in abstinent methamphetamine abusers: a possible compensatory response. Biol Psychiatry 2005; 57(9): 967-974.

Chang L, Smith LM, LoPresti C, Yonekura ML, Kuo J, Walot I, Ernst T. Smaller subcortical volumes and cognitive deficits in children with prenatal methamphetamine exposure. Psychiatry Res 2004;132(2): 95-106.

Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 2001; 14(1): 21-36.

Hanlon CA, Canterberry M. The use of brain imaging to elucidate neural circuit changes in cocaine addiction. Substance Abuse and Rehabilitation 2012; 3: 115-128.

Jacobsen LK, Giedd JN, Gottschalk C, Kosten TR, Krystal JH. Quantitative morphology of the caudate and putamen in patients with cocaine dependence. Am J Psychiatry 2001; 158(3): 486-489.

Jernigan TL, Gamst AC, Archibald SL, Fennema-Notestine C, Mindt MR, Marcotte TD, Grant I. Effects of methamphetamine dependence and HIV infection on cerebral morphology. Am J Psychiatry 2005;162(8): 1461-1472.

Kim SJ, Lyoo IK, Hwang J, Chung A, Hoon Sung Y, Kim J, Renshaw PF. Prefrontal grey-matter changes in short-term and long-term abstinent methamphetamine abusers. Int J Neuropsychopharmacol 2006. 9(2): 221-228.

Mahoney JJ 3rd, Kalechstein AD, De La Garza R 2nd, & Newton TF. Presence and persistence of psychotic symptoms in cocaine- versus methamphetamine-dependent participants. Am J Addict 2008; 17(2): 83-98.

Marinelli-Casey P, Gonzales R, Hillhouse M, Ang A, Zweben J, Cohen J, Rawson RA. Drug court treatment for methamphetamine dependence: treatment response and posttreatment outcomes. J Subst Abuse Treat 2008; 34(2): 242-248.

McKetin R, McLaren J, Lubman DI, Hides L. The prevalence of psychotic symptoms among methamphetamine users. Addiction 2006; 101(10): 1473-1478.

Mobius C, Kustermann A, Struffert T, Kornhuber J, Muller HH. c-MRI findings after crystal meth abuse. J Addict Med 2014; 8(5): 384-385.

Narayana PA, Datta S, Tao G, Steinberg JL, Moeller FG. Effect of Cocaine on Structural Changes in Brain: MRI Volumetry using Tensor-Based Morphometry. Drug and alcohol dependence 2010; 111(3): 191-199.

Rawson RA, Gonzales R, Marinelli-Casey P, Ang A. Methamphetamine dependence: a closer look at treatment response and clinical characteristics associated with route of administration in outpatient treatment. Am J Addict 2007; 16(4): 291-299.

Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Dunbar GC. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998; 59(20): 22-33.

Thompson PM, Hayashi KM, Simon SL, Geaga JA, Hong MS, Sui Y, London ED. Structural abnormalities in the brains of human subjects who use methamphetamine. J Neurosci 2004; 24(26): 6028-6036.

Vienna U. N. O. o. D. a. C. World Drug Report. New York: united Nations 2012.

Vienna, U. N. O. o. D. a. C. World Drug Report. New York: united Nations 2013.

Weller RE, Stoeckel LE, Milby JB, Bolding M, Twieg DB, Knowlton RC, Ding Z. Smaller Regional Gray Matter Volume in Homeless African American Cocaine-Dependent Men: A Preliminary Report. The Open Neuroimaging Journal 2011; 5: 57-64.

Whitwell JL. Voxel-based morphometry: an automated technique for assessing structural changes in the brain. J Neurosci 2009; 29(31): 9661-9664.

Supporting Agencies

This study was supported by Kermanshah University of Medical Science (Grant No: 96413).

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