DOI: 10.14704/nq.2018.16.6.1663

Comparison of the Effects of Total Intravenous Anesthesia and Intravenous Inhalational Anesthesia on Brain Metabolism during Surgery

Zijin Shen, Jianhua Qiu, Zhiyuan Wang, Rong Dong


To compare the effects on the brain metabolism of propofol-remifentanil total intravenous anesthesia and desflurane-remifentanil intravenous inhalational anesthesia in neurosurgery. Methods: Thirty-four neurosurgical patients with intracranial space-occupying surgery were randomly divided into two groups: Group A was conducted with the propofol-remifentanil total intravenous anesthesia and Group B with desflurane-remifentanil intravenous inhalational anesthesia. The patients were monitored for the brain metabolism prior to anesthesia, 1 hour after surgery, 2 hours after surgery, and half an hour after surgery. Results: The cerebral venous oxygen saturation, jugular bulb oxygen partial pressure, jugular vein oxygen content, and arterial oxygen content of the patients in group B were significantly higher than that of group A (P<0.001); arterial-jugular oxygen content difference and brain oxygen uptake rate of group B were lower than that in group A. Conclusions: (1) Both anesthesia methods can reduce the cerebral oxygen consumption and brain oxygen uptake, and thus reduce the cerebral oxygen metabolism.


Total Intravenous Anesthesia, Intravenous Inhalational Anesthesia, Surgery, Cerebral Metabolism

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